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1. Lee Sang-hyeok (Faker)

Lee Sang-hyeok, also known as Faker, is a professional League of Legends player from South Korea. Faker is widely considered one of the best League of Legends players in history, having won three world championships with his team, SK Telecom T1. However, despite his success, Faker has faced his fair share of setbacks and hardships throughout his career.

One of the most notable setbacks was in the 2017 League of Legends World Championship Finals. Despite being considered the clear favorite to win, Faker and his team were defeated by Samsung Galaxy 1-3 in the finals. This loss was a devastating blow for Faker, who had worked tirelessly for months to prepare for the tournament.

In addition to this loss, Faker has also faced criticism and scrutiny from fans and commentators alike. Despite his incredible skill and success, there are those who argue that Faker's game-play is too conservative and that he is not as innovative as some of his peers.

Despite these setbacks, Faker continues to be one of the most respected and successful players in the history of the game. His dedication and hard work have earned him a massive following of fans around the world, and he remains one of the most beloved figures in the League of Legends community.

2. Jian "Uzi" Zihao

Jian "Uzi" Zihao is a retired professional League of Legends player from China. Uzi was widely considered one of the top players in the world and was known for his incredible mechanical skill and aggressive playstyle.

Despite his success on the international stage, Uzi faced a number of challenges throughout his career. One of the most significant of these challenges was a chronic shoulder and arm injury that he developed while playing the game.

The injury made it difficult for Uzi to continue competing at the highest level, and he was forced to take multiple breaks from the game in order to heal and recover. In addition to his injury, Uzi also faced criticism from some members of the League of Legends community who felt that his aggressive playstyle was too risky and often resulted in costly mistakes.

Despite these challenges, Uzi remained one of the most talented and respected players in the world, and his skill and determination inspired countless fans around the globe.

3. Mohammed "MoAuba" Harkous

Mohammed "MoAuba" Harkous is a professional FIFA player from Germany. MoAuba's career is notable for the incredible amount of success he has achieved in a relatively short period of time, having won multiple championships and accolades since his debut on the professional scene.

While his success is undoubtedly impressive, MoAuba's career has also been marked by a number of setbacks and struggles. One of the most notable of these was his performance in the 2020 FIFA eWorld Cup, where he was considered one of the favorites to win but was ultimately eliminated in the group stage.

In addition to this disappointment, MoAuba has also faced criticism and backlash from fans and other players for his aggressive and sometimes confrontational behavior on social media and during competitions.

Despite these challenges, MoAuba remains one of the most talented and successful players in the world of professional FIFA, and his passion and dedication continue to inspire and captivate fans around the globe.

4. Steve "Shack" Shacklock

Steve "Shack" Shacklock is a retired professional Counter-Strike player from Australia. Shack is widely considered one of the pioneers of professional gaming in Australia, having played a pivotal role in the growth and development of the scene in his home country.

Despite his contributions to the community, Shack's career was plagued by a number of setbacks and challenges. One of the most significant of these was his struggle with mental health issues, which were exacerbated by the intense pressure and expectations of competitive gaming.

Shack's mental health struggles ultimately led him to retire from professional gaming in 2003, and he has since become an advocate for mental health awareness in the gaming community.

Despite the challenges he faced in his career, Shack remains a beloved and respected figure in the Australian gaming community and his legacy continues to inspire and motivate players around the globe.

5. Xu "BurNIng" Zhilei

Xu "BurNIng" Zhilei is a retired professional Dota 2 player from China. BurNIng is widely considered one of the greatest players in the history of the game, having won numerous championships and accolades over the course of his career.

Despite his success, however, BurNIng's career was marred by a number of setbacks and challenges. One of the most notable of these was a chronic hand injury that he developed while playing the game.

The injury made it difficult for BurNIng to continue competing at the highest level, and he was forced to retire from professional gaming in 2017 as a result.

Despite the challenges he faced, BurNIng remains one of the most talented and revered players in the history of Dota 2, and his legacy continues to inspire players around the world to this day.